Dr Anna Barnard – Group Leader
Anna is a Junior Research Fellow in the Department of Chemistry and the Insitute of Chemical Biology. Her JRF is sponsored by Professor Ed Tate at Imperial and Tony Holder at the Francis Crick Institute.
After graduating with an MChem degree from Durham University in 2008, Anna began a PhD in Chemistry with Professor David Smith at the University of York on self-assembling dendrons with applications in gene delivery which included a research visit at the University of Illinois. From 2012, she worked as a post-doctoral research associate with Professor Andy Wilson at the University of Leeds for 2 years on the development of novel inhibitors of protein-protein interactions. She then carried out a post-doc at Imperial College with Ed Tate for one year until the start of her JRF position in October 2015.
Dr Fiona Rowan – Post-doctoral Research Associate 2017-Present
After completing my BSc (Biochemistry) at Cardiff and MRes (Biochemical Research) at Imperial, I spent a year working in the structural biology group at Evotec. Following this, I took up a PhD at the Institute of Cancer Research, where my project involved selective chemical modification of amino acids within a protein kinase to modify its activity and conformation. I then spent two years working as a postdoc with Ali Tavassoli (Southampton) validating cyclic peptide inhibitors of PPIs involved in cancer and bacterial infection. In January 2017 I moved back to Imperial to join the Barnard group.
My project involves the design and validation of peptide antagonists of Doc, a bacterial protein responsible for persistent infections and resistance to antibiotics. By inhibiting the action of this protein, resistant bacteria could be re-sensitised to existing antibiotics.
Theo Flack – PhD Student 2015-Present
I graduated with an MSci in chemistry from the University of Bristol in 2014. During my Erasmus year in France, I designed and synthesised template-assembled catalytic G-quartets under the supervision Nicolas Spinelli at UJF/CNRS Grenoble. My final year project in Bristol was supervised by Dek Woolfson and focused on the de novo design of higher-order coiled-coils.
In October 2015, I joined Imperial College London under the supervision of Anna Barnard, Ed Tate and Tony Holder (Francis Crick Institute). My project aims to create a novel class of multi-facial helix mimetics for the inhibition of fully-buried protein-helix interactions. Initially, the mimetics will be designed to antagonise the MTIP-MyoA interaction in Plasmodium parasites.
Dan Miles – MRes in Drug Discovery Student 2016/17
I graduated from the Univeristy of Exeter in 2016 with a BSc in Biological and Medicinal Chemistry. In my final year I synthesised and tested colourimetric spiropyran-based sulfide anion sensors in the group of Alexis Perry.
I am currently studying for an MRes in Drug Discovery and Development at Imperial College London. My project is supervised by Anna Barnard and Matt Fuchter; it aims to crosslink α-helix peptides with azopyrazole photoswitches for the purpose of inhibiting protein-protein interactions in cancer.
Yinchao Wang – MRes in Drug Discovery Student 2016/17
I graduated from Imperial College London with a BSc Chemistry degree in 2016 where I worked on the synthesis of tetra-zinc catalysts for copolymerization of epoxides and carbon dioxide in the group of Charlotte Williams for my final year project. In the summer of 2016, I worked as a research intern at Wenjun Tang’s group in the Shanghai Institute of Organic Chemistry on the synthesis of natural product (+)-minfiensine.
I am currently an MRes Drug Discovery and Development student working with Anna Barnard on helix mimetic inhibitors against myosin tail interacting protein in malaria parasites. The starting point of my project is aiming to develop the synthesis route for aromatic oligoamide building blocks to interact across multiple binding interfaces.
I am a visiting Erasmus student from the Friedrich-Alexander university Erlangen-Nuremberg, Germany, where I am a last year M.Sc. student of medicinal chemistry. During my time in Anna Barnard’s group, I am developing novel small molecule ligands to prevent malaria transmission.