Unlocking the KLK activome in drug-resistant cancer: imaging, biomarkers and target validation using novel activity probes

This 4-year PhD studentship is funded by Cancer Research UK, and is open to all residents of the European Union; it offers an enhanced tax-free stipend of £21000 pa, plus support for conference travel. The project would ideally suit an outstanding Masters level chemist, medicinal chemist or chemical biologist, with some research experience in synthetic chemistry and/or chemical biology, and a strong interest in developing and applying novel chemical tools in the context of cancer diagnostics and therapeutics. As the student on this project you will be at the centre of a multidisciplinary collaboration to develop a versatile chemical probe platform for the KLK activome in prostate and ovarian cancers. You will design, synthesise and test optimised probes for specific KLKs through a combination of solution and solid phase chemistries, and advanced high-throughput screens. You will apply these chemical proteomic tools to understand KLK dynamics, identify KLK activity biomarkers, image KLK activities in cells and in preclinical animal models, and drive validation of potential drug targets. For full details see CRUK PhD Studentship 230417 advert.pdf

Next generation polyfunctional probes for chemical biology

This 4-year Industrial CASE PhD studentship is funded by GlaxoSmithKline and EPSRC, and is open to all residents of the EU/EEA and Switzerland. The project would ideally suit an outstanding Masters level chemist, medicinal chemist or chemical biologist, with research experience in synthetic chemistry and/or chemical biology, and a strong interest in developing and applying chemical probes for biological systems. As the student on this project, you will be at the centre of a collaboration between scientists at Imperial, GSK and Cellzome, interacting with internationally leading groups in the field of chemical probes and protein modification. You will design, synthesise and apply new polyfunctional probes with the capacity to modulate drug targets with exquisite spatiotemporal precision, exploiting photoactivated switching and conjugation, in-cell probe assembly, and multivalent ligands which can ‘rewire’ protein complexes to generate novel functions from pre-existing cellular components. For full details see Imperial/GSK/Cellzome PhD.pdf

Other PhD studentships

Any students interested in pursuing postgraduate research in our group should contact me directly; all prospective applicants should have or expect to obtain a 1st class honours degree (or equivalent) in chemistry, biochemistry, or a closely related discipline; non-UK students must be able to obtain independent funding for their studies, e.g. via a government bursary.

Postdoctoral opportunities

We welcome informal enquiries from potential postdoctoral fellows with outstanding research track records who are prepared to apply for independent research funding, for example from the European Union, HFSP, etc. Full assistance will be given in preparing a competitive research proposal; we have an exceptional track record in accelerating the careers of outstanding postdoctoral researchers, with six Marie Curie fellows in our lab in the past four years.