iGEM is an extremely important annual international student competition in synthetic biology, attracting teams from the world’s leading universities.

Since we entered our first iGEM team in 2006, we have consistently entered talented teams with innovative projects ranging from water purification solutions, to drug delivery mechanisms, to soil erosion preventions. You can find out more about each of our projects at the bottom of this page.

We are proud to have maintained our enviable position as the most successful UK, and probably international, university in the competition. This is despite the competition increasing in size from 32 teams in 2006 to 220 teams in 2014.

In both 2006 and 2014 Imperial placed second overall and each year won a gold medal and a raft of prizes. In total Imperial has achieved 8 gold medals and 17 major prizes and now has more than 60 alumniGEM.

Take a look at www.igem.org for more information.

iGEM

iGEM 2016 - Eco-librium

Congratulations to the Eco-librium team for being crowned overall winners of iGEM 2016. The team took the grand prize and five major prizes, and is the first team from Imperial College to win the prestigious award.

The team won the following prizes:

  • Overall Winner (Undergraduate)
  • Best Foundational Advance Project (and Gold Medal)
  • Best Education and Public Engagement
  • Best Wiki
  • Best New Basic Part
  • Best Poster

Title: Eco-librium: developing a framework for engineering co-cultures

Abstract:
In nature, microorganisms live together and cooperate to accomplish complex tasks. As synthetic biology advances, we transition from unicellular systems to engineering at the multicellular level. A major obstacle, however, is ensuring stable coexistence of different cell types in co-culture. This year we are developing a Genetically Engineered Artificial Ratio (GEAR) system to control population ratio in microbial consortia. Our device will employ a bi-directional communication system and novel RNA control that can be implemented across different bacterial strains. We are also developing software to facilitate the design and optimisation of co-cultures. In the future, we envision the GEAR system being used for microbiome engineering as well as distributed multicellular biocomputing and bioprocessing.

Visit the team website for more information.

iGEM 2014 - Aqualose

OVERALL FIRST RUNNERS-UP

Winner: Best part collection

Winner: Best manufacturing project

Commendation: Policy and practices

Bacterial cellulose (BC) is a natural biomaterial with high purity compared with plant-derived cellulose and better mechanical properties. With more than half of the global population facing water stress in 2025 due to rising freshwater supplies, we focused on the application of BC to the global issue of water purification. As a means to improve water purification, we decided to pursue functionalised BC water filtration membranes. For this, we functionalised BC with proteins, created a toolkit for the native producer G. xylinus, sequenced its genome, transferred the cellulose synthesis operon to E. coli, mass produced BC and characterised its mechanical properties. The porosity of BC and our synthetic attachment of contaminant-specific binding proteins make for a customisable ultrafiltration membrane. This product has the potential to augment water recycling on local and industrial scales, helping to alleviate water stress.

Visit the team's website for more information

iGEM 2013 - Plasticity

OVERALL SECOND RUNNERS-UP

Winner: Best Manufacturing project

Award: Gold Medallist

Award: Best New BioBrick Part or Device, Engineered


We have taken an expensive by-product of recycling facilities, a type of mixed waste and turned it into something quite amazing; a material that can be used for a diverse range of applications from making your lunchbox to a 3D printed tissue scaffold. This material is the bioplastic poly-3-hydroxybutyric acid P(3HB). Our system is designed to maximise the recovery of resources from the waste and so we have also investigated how we can use the oil based plastics within it. We are passionate about using synthetic biology to help us move towards a more sustainable economy. We have considered what happens to the material we produce after it is used. This led us to develop the first synthetic biology recycling system for P(3HB).

iGEM 2011 - Auxin

Imperial College London iGEM 2011 wiki

EUROPEAN CHAMPIONS

OVERALL FIRST RUNNERS-UP

Winner: iGEMmers Prize (tie with Tokyo)

Winner: Best Poster (tie with Wash U)

Winner: Best European Wiki

Awards: Gold Medallist; Special Safety Commendation

 

In an effort to combat soil erosion, we have developed the Auxin system. This system is comprised of three modules combined in an E. coli chassis. The first involves secretion of the plant growth factor indole 3-acetic acid (auxin). This plant hormone will promote root growth which is essential for anchoring soil.

The second module rewires the chemotactic mobility of the cell by introducing a novel receptor protein which is sensitive to root exudates. The bacteria can then be naturally taken up by root cells for targeted auxin delivery. The final module uses a toxin-antitoxin system to prevent horizontal gene transfer. While the plasmid containing the AuxIn system can be maintained inside our chassis, it will induce lysis in any other bacteria. By improving root growth, the AuxIn system provides a synthetic biology approach to tackling worldwide problems such as soil erosion and desertification.

iGEM 2010 - Parasight

Imperial College London iGEM 2010 wiki

FINALIST

Winner: Best Human Practices Advance

Winner: Best Wiki (tie with Cambridge)

Awards: Gold Medallist; iGEMers Prize

 

More than two billion people around the world live with unrelenting illness due to parasites. Synthetic biology offers great opportunity for biosensors, however current designs require hours before useful output. To tackle this issue in the field, it's crucial that a biosensor responds in minutes, hence we have engineered a fast, modular sensor framework.

This allows detection of a range of different parasites, and may also be used as an environmental tool for mapping their spread. We have developed two new technologies that enable our modular input/output - a novel cell surface biosensor, customisable for specific parasitic proteases, linked through quorum-sensing to a new 'fast-response' module capable of producing a detectable output in minutes. To demonstrate the concept, we've designed and fabricated B. subtilis to give a striking colour readout upon detecting the waterborne Schistosoma parasite which affects 200 million people worldwide.

iGEM 2009 - The E.ncapsulator

Imperial College London iGEM 2009 wiki

FINALIST

Winner: Best Manufacturing

Winner: Best Human Practices (tie with Paris)

Award: Gold Medallist

 

Our 2009 entry attempted to solve the problem of targetting drugs to the intestine - the harsh environment of the stomach providing a daunting barrier. E. coli was tuned to produce colanic acid, a protective protein which surrounds the bacteria and protects it from acid erosion, in response to a stimulus. In addition devices were added to allow production of a drug prior to encapsulation and to destroy DNA in the cell afterward.

The project's multiple 'stages' - growth, drug production, encapsulation and attenuation - posed a challenge; how to trigger each when needed? Parts were incorporated at each stage that responded to a different stimulus - a chemical, lack of nutrients, heat and so on. This allowed fine control over the level of drug produced. The post-encapsulation destruction of the DNA in the cells (rendering them inert) in response to a trigger won us the joint Best Human Practices Advance award.

5 bioengineers and 3 life scientists made up the team, and we again came away from the Jamboree with the Best Manufacturing Project award, as well as reaching the final!

iGEM 2008 - Biofabricator subtilis

Imperial College London iGEM 2008 wiki

Winner: Best Manufacturing

Winner: Best Part

Award: Gold Medallist

 

This project focu ssed on turning Bacillus subtilis, a Gram-positive bacteria, into a biomaterial factory. The aim was to quickly and accurately immobilise motile bacteria by engaging a flagellar 'clutch' mechanism (a molecule called EpsE disengages the flagellum from the motor protein; we showed it worked effectively to halt bacteria and the epsE gene won us the Best Part award) in response to a light input, which would also trigger the production of biomaterial. Thus a light mask could provide the template for laying down e.g. collagen at very high resolution.

This project was ambitious as B. subtilis was a new organism to the competition, meaning we had to add all the basic parts - promoters, ribosome binding sites - to the Registry ourselves! We contributed 45 parts to the newly-formed 'B. subtilis' section of the Registry, including integration sequences which allow devices to be integrated directly onto the genome of a chassis.

The team consisted of 5 bioengineers and 4 life scientists, and at the Jamboree in Boston we won our track (Manufacturing)!

iGEM 2007 - Infector Detector

Imperial College London iGEM 2007 wiki

Award: Gold Medallist

 

The 2007 team focused on a medical project; producing a device that could detect urinary tract infections on catheters. These infections can spread up into the body, posing health risks to the patient; simply changing the catheter at the first stage of infection (biofilm formation) can solve the problem, but it is currently impossible to easily determine if a biofilm is being formed.

The team put together a few simple but effective parts to try and get around this issue - a detector that responds to the presence of a molecule expressed by bacteria undergoing biofilm formation, an amplifier to boost that signal and a reporter protein. Combined, these parts form a device which gives a visible cue that bacteria are gaining a hold and an infection could be imminent - with the amplifiction meaning that a compromised catheter can be noticed and replaced early in the infection cycle.

Because of the difficulty of using microorgan isms as chassis for this application, the team looked into the use of cell-free systems to allow the device to be deployed without the need for a delicate (and possibly dangerous!) host cell.

5 life scientists and 5 bioengineers formed the 2007 team, and the project is still ongoing - the aim is to eventually produce the Infector Detector as an actual medical device to use in hospitals!

iGEM 2006 - I.coli

Imperial College London iGEM 2006 wiki

FIRST RUNNER-UP

Winner: Best Documentation

Winner: Best Characterisation

Award: Gold Medallist

2006 was Imperial's first year at iGEM, and we definitely made an impression! Coming second overall, our project was an attempt at that most elusive of biological systems - a stable genetic oscillator. Inspired by the Lotka-Volterra model of predator/prey interaction, which sees two populations rising and falling in a manner reliant on each other, two cell lines were made to emulate a predator/prey relationship.

Robust modelling and in silico production of the system beforehand allowed the build to progress at a rapid pace; all necessary parts and devices - including both complete predator and prey cells - were modelled, built and tested and the level of characterisation and accurate, relevant documentation of th e parts and project won us the awards in those areas.

The team included 4 bioengineers, 3 life scientists and an Electronic & Electrical Engineer and came second overall in the competition!