Grace Birch, PhD student in the Department of Medicine talks about her work funded by the MS Society.

Multiple Sclerosis Society funding

Multiple Sclerosis Society funding

Grace Birch, PhD student in the Department of Medicine talks about her work funded by the Multiple Sclerosis Society. Grace is working on a project that aims to understand how a population of white blood cells - called natural killer cells - might modulate disease in Multiple Sclerosis.

PhD student accolades

Malcolm Sim

Malcolm Sim, Wellcome Trust-NIH PhD student in the Department of Medicine published his work in the European Journal of Immunology. For further information, please see the full article - 'KIR2DL3 and KIR2DL1 show similar impact on licensing of human NK cells'.

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity published in Nature


Nature. 2017 Jan 5;541(7635):81-86. doi: 10.1038/nature20784. Epub 2016 Dec 21.

Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of developing type 2 diabetes, cardiovascular disease and related metabolic and inflammatory disturbances. This epigenome-wide association study published in Nature supported by the NIHR BRC FACS and Confocal Imaging Facility (Hammersmith Campus) shows that body mass index is associated with widespread changes in DNA methylation. Genetic association analyses demonstrated that the alterations in DNA methylation are predominantly the consequence of adiposity and that methylation loci are enriched for functional genomic features in multiple tissues. The methylation loci identified genes involved in lipid and lipoprotein metabolism, substrate transport and inflammatory pathways. These disturbances in DNA methylation predict future development of type 2 diabetes. The study provides new insights into the biologic pathways influenced by adiposity, and may enable development of new strategies for prediction and prevention of type 2 diabetes and other adverse clinical consequences of obesity.

PMID: 28002404 DOI: 10.1038/nature20784