In response to the current paradigm shift and clinical demand in bringing cellular and molecular imaging modalities to an in vivo – in situ setting to allow for real-time tissue characterization, functional assessment, and intraoperative guidance, we have an active research programme on biophotonics with specific focus on in situ, in vivo tissue characterization and surgical guidance. Our key research interests include development and application of photonics technology to surgical imaging and surgical robotics, which include the development of imaging catheters for fluorescence lifetime imaging (FLIM), multispectral polarization sensitive laparoscopes with MEMS controlled spectral selection, probe-based endo-microscopes, illumination optics for flexible robotic endoscopes and optical detection of gold nanoparticles and thermal therapy.

Selected publications

Howitt 2012Cheng Y, Li S, Eckersley RJ, Elson DS, Tang MX
Viscosity measurement based on shear-wave laser speckle contrast analysis
Neuroimage. 2013 Jan 1;64:267-76

Howitt 2012Su L, Cloyd KL, Arya S, Hedegaard MA, Steele JA, Elson DS, Stevens MM, Hanna GB
Raman spectroscopic evidence of tissue restructuring in heat-induced tissue fusion
J Biophotonics. 2013 Nov 15

Howitt 2012Qi J, Ye M, Singh M, Clancy NT, Elson DS
Narrow band 3 × 3 Mueller polarimetric endoscopy
Biomed Opt Express. 2013 Oct 11;4(11):2433-49

Howitt 2012Hughes M, Yang GZ
Robotics and smart instruments for translating endomicroscopy to in situ, in vivo applications
Comput Med Imaging Graph. 2012 Dec;36(8):589-90

Howitt 2012Clancy NT, Stoyanov D, James DR, Di Marco A, Sauvage V, Clark J, Yang GZ, Elson DS
Multispectral image alignment using a three channel endoscope in vivo during minimally invasive surgery
Biomed Opt Express. 2012 Oct 1;3(10):2567-78

Howitt 2012Elson D, Anvari B
Biophotonics in bioengineering
Ann Biomed Eng. 2012 Feb;40(2):250