About us

Funding

The Glycosciences Laboratory has been supported by research project and programme grants from the MRC, Wellcome Trust, BBSRC, EPSRC, and the NCI Alliance of Glycobiologists the US National Institute of Health.

Current funding:

  • Wellcome Trust Biomedical Resource Grant (since 2012) to support the Carbohydrate Microarray Facility. 
  • NCI Alliance of Glycobiologists (2012-2017) entitled “Carbohydrate Antigenic Biomarkers for Epithelial Cancers”.
  • Leukaemia and Lymphoma Research grant (2014-2017) entitled “Carbohydrate antigen recognition by the B-cell receptors of chronic lymphocytic leukaemia and lymphoma cells”.
  • Royal Society International Exchanges grant (2015-2017) entitled “Chromatography of gangliosides and their oligosaccharides for glycome microarray”.
  • BBSRC/EPSRC/Innovate UK: Industrial Biotechnology Catalyst Early Stage Translation grant [(2015-2020) PI Dr Bruno Linclau (Southampton University) entitled “Chemo-enzymatic Production of Specialty Glycans”].

Equipment

Robotic arrayers for generating microarrays of lipid-linked glycan probes, polysaccharides and glycoproteins

  • PerkinElmer's Piezorray
  • GeSiM - Nano-Plotter 

Fluorescent microarray scanners used to quantify fluorescent signals on microarrays

  • PerkinElmer ProScanArray
  • GenePix 4300A Scanners with Automated Slide Loader

Mass Spectrometers used for carbohydrate composition and sequence analyses

  • ESI-MS instrument with a Q-TOF configuration (Waters SYNAPT G2-S)
  • MALDI mass spectrometer with an Ion-Trap/TOF configuration (Shimadzu Axima Resonance)
  • MALDI mass spectrometer with a linear TOF configuration (Shimadzu Axima Assurance)
  • GC-MS system (FinniganTrace MS)
  • NMR spectrometers for carbohydrate structure determination and carbohydrate-protein interaction studies

Access at MRC Biomedical NMR Center  (now part of the Francis Crick Instituteto

  • 700 MHz Bruker cryoprobe NMR spectrometers