Applications are invited for a Postdoctoral Research Associate to join the laboratory of Dr. Doryen Bubeck.   The post, funded by Cancer Research UK, provides an exciting opportunity to work as a key member of an interdisciplinary structural biology project involving high resolution electron cryo-microscopy that has the potential to impact actively prescribed cancer therapeutics. 

The project involves structural and functional characterization of protein complexes involved in the complement terminal pathway.   

Complement plays an important role in monoclonal antibody (mAb)-based cancer immunotherapy through complement-dependent cytotoxicity (CDC). One mechanism of tumor clearance is by the deposition of membrane attack complex (MAC) pores on target cells. The effectiveness of CDC remains limited in some cancers due to over expression of CD59, a membrane-bound complement regulator that inhibits MAC-mediated lysis. Broadly the goal of this project is to understand how MAC pores are assembled and regulated in lipid bilayers.

The Centre for Structural Biology is a state-of-the-art electron microscopy facility equipped with two FEG electron microscopes and cutting edge dectectors (4k x 4k CCD and FEI Falcon II direct electron detector). The project will involve regular access to Titan Krios facilities at eBIC (Diamond Light Source, UK) and IGBMC-CERBM (Strasbourg, France).

Closing date: 17 February 2016




Full-time, fixed term for up to 4 years from 01 April 2016

We wish to recruit a Research Associate to work in the research group of Professor Xiaodong Zhang (www.msf.bio.ic.ac.uk), in the Section of Structural Biology, Department of Medicine, at Imperial College London’s South Kensington Campus. The successful candidate will join a multi-disciplinary team of international researchers investigating the structures and mechanisms of bacterial RNA polymerase inhibition and activation. We employ a combination of Biochemistry, X-ray crystallography and electron microscopy techniques, utilising our excellent protein production and structural biology facilities at Imperial College London.

You must hold a PhD, or equivalent, in biochemistry, structural biology or relevant discipline and have a demonstrated track record in conducting high quality original research. Knowledge in protein biochemistry and structural biology as well as experience in protein expression and purification are essential.

For informal enquiries please contact Professor Xiaodong Zhang xiaodong.zhang@imperial.ac.uk.

Closing date  - Sunday 7th February 2016