Claudia MenichiniI am a final year PhD student in the Department of Chemical Engineering. My research is focused on developing a mathematical model to predict thrombus formation in aortic dissection, one of the most catastrophic diseases that can affect the aorta. The model will be used to optimize treatment strategies in order to improve the survival chances of patients.

I completed my BSc in Chemical Engineering in Italy, and after taking one year off of studies to travel around Australia and South East Asia I have moved to London for an MSc in Advanced Chemical Engineering. Alongside my studies I am very passionate about travelling, I love challenging myself with new constructive experiences, meeting people from new countries, and learning more about their cultures. My long travels have also given me an opportunity to discover a passion for photography.

Biography

DateRole
 March 2014 - Present  

PhD student in Chemical Engineering

Imperial College London

September - December 2016

Junior Associate Intern

McKinsey & Company, Milan, Italy

 January-February 2015  

Visiting PhD student

University of Cape Town (UCT), Department of Human Biology

 2012 - 2013  

MSc in Advanced Chemical Engineering with Biotechnology

Imperial College London

 2008 - 2011  

MSc in Advanced Chemical Engineering with Biotechnology

Imperial College London

Summary of the table's contents

Research Interests

My research interests are quite broad, and include applications of fluid mechanics and transport phenomena in the study of biological and physiological systems, as well as analysis, design, and optimizations of bio-processes and water treatments. My current project is focused on the formulation of a mathematical model to predict the formation of thrombus in aortic dissection, and to gain better insight into the development and progression of this catastrophic disease. This involves the use of CFD software and numerical tools for the solution of complex fluid dynamics problems, and the image-based analysis of patient specific models. In the past I have carried out both modeling and experimental studies of bio-processes for wastewater treatment and production of energy from biomasses in microbial fuel cells.

Project Title

"Predicting thrombus formation in patient-specific Type B aortic dissection."

The outcomes of patients affected by Type B aortic dissection are affected by the formation of thrombosis in the false lumen. If it was possible to predict which patients would go on developing thrombus formation and to what extent, treatments could be significantly improved.

This project focuses on the development of a mathematical model to predict thrombosis in aortic dissection based on the analysis of hemodynamic parameters. Such a model will permit to gain better insight in the development and progression of aortic dissection, and will provide powerful information to predict future evolutions and optimize endovascular and medical treatments. 

Supervisor(s)

Prof Xiao Yun Xu

Department of Chemical Engineering, Imperial College London, UK

Conferences

C. Menichini, Z. Cheng, R.G.J. Gibbs, X.Y. Xu, Patient-specific prediction of False Lumen Thrombosis in Type B Aortic Dissection. The 16th International Conference on Biomedical Engineering (ICBME 2016), Singapore, 7 - 10 December 2016 (Invited oral presentation).

C. Menichini, Z. Cheng, R.G.J. Gibbs, X.Y. Xu, Predicting False Lumen Thrombosis in 3D Patient-Specific Models of Type B Aortic Dissection. Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C 2016), National Harbor, MD, USA, June 29 - July 2, 2016 (Oral presentation). 

C. Menichini, X.Y. Xu, Mathematical Modeling of Thrombus Formation in Idealized Models of Aortic Dissection. Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C 2015), Snowbird resort, Utah, USA, 17-20 June 2015 (Poster presentation). 

C. Puchongkawarin, C. Menichini, C. Laso-Rubido, S. Fitzgerald, B. Chachuat, Towards a New  Understanding of the Balance between Energy Use and Effluent Quality, Enviro14, Adelaide, Australia

C. Puchongkawarin, C. Menichini, C. Laso-Rubido, S. Fitzgerald, B. Chachuat, Model-based Methodology for Plantwide Optimization of WWTPs: A Case Study,  2nd IWA Specialist Conference on EcoTechnologies for Sewage Treatment Plants 2014, Verona, Italy.

Publications

C. Menichini, Z. Cheng, R.G.J Gibbs, X.Y. Xu, Predicting false lumen thrombosis in patient-specific models of aortic dissection. Journal of the Royal Society Interface, 2016.

C. Menichini, X.Y. Xu, Mathematical Modeling of Thrombus Formation in Idealized Models of Aortic Dissection - Initial findings and potential applications. Journal of Mathematical Biology 2016; 73(5): 1205-1226

C. PuchongkawarinaC. Menichinia, C. Laso-Rubido, S. Fitzgerald, B. Chachuat. Model-based Methodology for Plant-wide Analysis of Wastewater Treatment Plants: Industrial Case Study. Journal: Water Practice and Technology, Vol 10 No 3 doi: 10.2166/wpt.2015.059. aEqual contributors. 

Awards and Funding

2016: "Postgraduate Academic Rep Team of the Year", Imperial College Union. 

2015: "IC Trust travel grant", to present at the Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C 2015), Snowbird resort, Utah, USA, 17-20 June 2015.

2014 - 2017: "Chemical Engineering PhD Scholarship", fully funded PhD scholarship awarded by the Department of Chemical engineering, Imperial College London.

2013: "Geoffrey Hewitt Prize", awarded by the Department of Chemical Engineering at Imperial College to the most outstanding MSc student in Advanced Chemical Engineering.

Teaching Experience

2015 - 2016: Mathematics tutor

Autumn 2015: Undergraduate lab supervisor

2014 - 2017: Graduate Teaching Assistant (GTA) and Lab Supervisor for Knowledge (2nd year) laboratory. Taught and  experiments including Compressible Flow,  PV Isotherms, Continuous and Batch Distillation, and Heat Exchanger Design. 

Summer 2015: GTA for summer school program for Georgia Institude of Technology, University of Notre Dame, and Cornell University. Taught and demonstrated different lab experiments, including Continuous Distillation, Pipe Flow, and Flow Lines. 

Extra-Curricular Activities

2014 - 2016: Transport and Separation PhD Representative, Department of Chemical Engineering, Imperial College London.  

Contacts

Office

ACEX 1M17, Department of Chemical Engineering

Imperial College London, South Kensington Campus

London, SW7 2AZ, UK

Office Phone 

+44 (0)207 594 2562

E-mail

claudia.menichini12@imperial.ac.uk